Test UsageĬortisol is the primary glucocorticoid of the adrenal cortex. Consider pituitary failure if low baseline cortisol, especially if below 170 nmol/L in morning. Synacthen tests: normal response is cortisol above 420 nmol/L on 30-minute sample. A normal response to Dexamethasone is suppression of Cortisol to less than 50 nmol/L. If clinical concern for Cushing’s, discuss testing methods with endocrinologist. Suspected Cushing’s syndrome should not be assessed with 9 am or random cortisol. If in doubt, discuss with an endocrinologist. Above 320 nmol/L makes adrenal failure unlikely if no strong clinical concern. Above 420 nmol/L normally excludes adrenal failure. Note – change of assay 22/06/16, results are now around 20% lower than before.įor suspected adrenal failure, a 9 am cortisol is a useful screening test.
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